pentobarbital will lessen the level or outcome of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Pitolisant exposure is decreased by 50% if coadministered with powerful CYP3A4 inducers.pentobarbital will lessen the extent or outcome of alprazolam by affecting hepatic/intestinal enzyme CY